May 01, 18 · Expanding the MSA therapeutic landscape beyond the oligodendrocyte, the neuronal pathology of MSA has not been so extensively explored While neuronal αsyn accumulation has been greatly studied (and targeted) in PD and other synucleinopathies, less is known of its potential as a target for MSA, and its interest has been mostly limited to actFeb 17, · Multiple system atrophy (MSA) is a debilitating and fatal neurodegenerative disorder The disease severity warrants urgent development of diseasemodifying therapy, but the disease pathogenesis is still enigmatic Neurodegeneration in MSA brains is preceded by the emergence of glial cytoplasmic inclusions (GCIs), which are insoluble αsynuclein accumulations withinResults MSAC cases with the lowest burden of pathology showed αsyn glial cytoplasmic inclusions (GCIs) in the cerebellum as well as in medullary and pontine cerebellar projections The Pathological Hallmark Of Msa Is The Presence Of Glial Cytoplasmic Download Scientific ...